Tissues, Cells and Molecules
Code
11105
Academic unit
NOVA Medical School|Faculdade de Ciências Médicas
Department
Cellular and Molecular Medicine
Credits
13
Teacher in charge
Prof. Doutor Miguel Seabra
Teaching language
Portuguese
Objectives
The UC of Tissues, Cells and Molecules aims to teach how the molecules and cells of human body behaves integrated in the tissues. We want the students learn the human tissues in a integrate form with the cells and the proteins that forms it.
Prerequisites
Student attendance to 2/3 of the practical classes is mandatory.
Subject matter
Molecules Modules (9 lectures)
Characterize cell membrane.
Known and characterize the diferentes levels of proteins structure.
Identify the proteins function, namely: cytoskeleton, molecular motors, mioglobin and hemoglobina. as funções proteicas nomeadamente: cytoskeleton, molecular motors, myoglobin and hemoglobin
Connect the structure to protein function.
Describe the enzymes and kinectics.
Cells Module (12 lectures)
Characterize the cell cycle and the principal events.
Identify and describe the nuclear processes: genic organization, DNA replication, DNA transcription and mRNA processing.
Describe the cell organization.
Describe, identify and characterize the cell organelles
Identify and characterize citoplasmic processes: proteins translation, modifications pos-translation, cell trakicking.
Signalling Module (3 lectures)
Describe and identify cell receptors and signaling strategies.
Describe, characterize and give examples of signaling pathways which involves G protein receptors, tyrosine kinases receptor, TGFb and GTPases.
Integration Module (4 lectures)
Integrate the processes of apoptosis, cell diferentiation and the form of cell to communicate.
General Histology Module ( 8 lectures)
Know to identify and characterize the different types of tissues, using the appropriate language and nomenclature.
Develop a mopho-functional unit between blood and its elements and circulation, the
Desenvolver uma unidade morfo - funcional entre o sangue e seus elementos figurados e os sistemas onde circulam, cardiovascular and lymphatic system.
Special Histology Module (11 lectures)
Systematic Histology Module (11 lectures)
The different organs and system will be analyzed by microscopy constitutive anatomy, as well as by cellular kinetics of different cells look for to identify and characterize it.
Seminars (3 lectures)
The seminars wil allow to the studentes to integrate the knoledgements obtained during the theoretical course, as well as to see what is done in science.
Bibliography
In addition to the copies of the slides used during the classes and provided by agreement of the professor, it is also suggested the following bibliography:
Lodish, Harvey et al.; Molecular Cell Biology; 4ª Edição; W. H. Freeman and Company.
Alberts, Bruce et al.; Molecular Biology of the Cell; Garland Publ. Inc.; New York.
Kierszenbaum, Abraham; Histology and Cell Biology; 3º or 4º Edition Mosby Elsevier
Young, B and Heah J. W., Wheaters Functional Histology, a text and colour atlas. 4º Edition Mosby Elsevier
Carlson, Bruce M.; Human Embryology and Developmental Biology; Mosby.
Costa, Celestino; Morato, Xavier; Desenvolvimento Embrionário dos Vertebrados; Edições Verbo.
Azevedo, Carlos (Coordenação); 5ª Edição; Biologia Celular e Molecular; Lidl Edições Técnicas Lda; Lisboa; 2013.
Teaching method
· Theoretical training: The theoretical classes will consist of lectures divided in modules and each week will be held four lectures of 50min each. The handouts will be in the Moodle platform at the end of each lecture, as well as, the specific learning aims.
· Pratical Training: The theoretical and practical lessons for each class have duration of 2 hours. Each class will have per week 4 hours of practical classes, in two shifts of 2 hours. The pratical classes will be held as a classical pratical laboratory training, case-study and microcopy classes.
Evaluation method
a) Evaluation methods
The evaluation process at Tissues, Cells and Molecules CU is composed by three components: practical evaluation, seminars and theoretical evaluation, structured as follows:
a.1) Practical evaluation component (40% of the final grade)
The grade obtained by the student in the practical component will include the performance and attendance of the students in practical classes, which are based on the following evaluation parameters: (i) Elaboration of practical work by module or practical class by each student or in group: The Case studys will be oral presented by each group, the teacher evaluate their performance, scientific capacity and solution of the case. If the student is not present at a class will be evaluated with 0 values in that class.
Resolution, performance in the laboratory during pratical work and
(ii) classes evaluation, which includes the students attitudes and knowledge demonstrated during the practical classes.
(iii) Practical Tests : 1th test will be on the 7th of November (schedule hour to be defined) room I, II and III. The students need to take a valid identification and a pen (only the answhers completed with pen are validated).
The 2nd test on 17 e 18 of December is in the practical room, during the schedule for each team.
Each part (i, ii and iii) count as 1/3 to the 40% of pratical evaluation.
If a student misses any of tests will be classified with 0 values.
The evaluation is continuous and quantitative, from 0 to 20 values and:
With a classification less than 9,5 values, the student have to repeat the practical part and have not access to the Final Exam.
With classification equal or superior to 9,5 values, the student have access to the Final Exam.
Special cases: Practical evaluation
Any student with a special statute, which is not mandatory to be present on the practical classes, to have access to the Final Exam have to do Practical Exam, on a date to combine with the responsible
a.2) Theoretical evaluation component (69% of the final grade)- Final Exam
The written final exam includes all the theoretical, seminars and practical subjects taught until the exam date.
This evaluation is quantitative from 0 to 20values and:
The student final grade higher than 9,5 values can be confirmed and/or modified by an oral exam. This oral exam is volunteer, but the student has to have a minimal classification of 9,5 values on the practical and theoretical components.
In the 1th or 2nd call the student need to have a minimal classification of 9,5values to be approved on the final exam of TCM (60% of the final grade)
Note: Whatever the exam call (1th, 2nd or Special) chosen by each student in order to do the Final Exam, is mandatory to have a Practical final grade equal or superior to 9,5 values and has to be valid (only the students from the last course have the grade of the practical valid).
If a student want to improve is grade, the evaluation will bem ade by written exam on the 2nd cal, and the grade of the exam is the final.
1st CALL OF EXAMS:
The final exam for the 1st call of exams is an written exam, which covers all theoretical, seminars and practical contents taught during the semester.
If a student on the 1th call have a classification less than 9,5 values ou miss the exam by other reason, can do it on the 2nd call. f the student does not go to any of the exam call will be disapproved.
2nd CALL OF EXAMS:
The final exam for the 2nd call of exams is an written exam, which covers all theoretical, seminars and practical contents taught during the semester.
If a student on the 2nd call have a classification less than 9,5 values ou miss the exam by other reason, will be disapproved (if is the case still the student still have the special call, see the FCM rules)
In the case of students who failed in the previous call of exams, the practical evaluation component will be saved, with a weighting of 40%, and the mark of the written exam will correspond to the remaining 60% of the final grade.
For students who wish to improve their grades, the evaluation will only be performed by an oral exam, whose classification corresponds to 100% of the final grade.
b) Evaluation criteria
The TCM CU evaluation is continuous and students should attend to 2/3 of practical classes. All theoretical and practical subjects taught, including seminars, will be evaluated in this CU.
To perform the final written examination the mark obtained in practical component, must be greater than or equal to 9,5 values (out of 20); otherwise, the student failed the of TCM CU
If the student does not attend more than 2/3 of practical classes, there is no way to compensate for the lack of student attendance. For students with student-worker status and high-competition athletes who do not attend class practices, a practical examination will be performed within the academic calendar, at a time to be deal with the course director.