Pharmaceutical Biochemistry
Code
10718
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
6.0
Teacher in charge
José Ricardo Ramos Franco Tavares
Weekly hours
4
Total hours
57
Teaching language
Português
Subject matter
1. Introduction and definitions in Pharmaceutical Biochemistry
2. Drug Biotransformation Systems
3. Drug metabolism: CYP-mediated oxidation and reduction
4. Induction of Cytochrome P450 Systems
5. Cytochrome P450 Inhibition
6. Effects of Diet on Drug Metabolism
7. Experimental Methods in Drug Metabolism Studies
Bibliography
Human Drug Metabolism: An Introduction, 2nd Edition
Teaching method
Theoretical classes are presentation of the themes by the Professor. Theoretical-practical classes are learning and practice of computational methods for the analysis of the drug-protein interaction. Practical classes are presentation of group seminars about a drug or family of drugs, of choice by the group.
Evaluation method
Practical evaluation (30% final grade) based on the presented Seminar as well as on questions made to colleagues during the discussion period of their Seminar presentation.
Both the theoretical (40% final grade), and the theoretical-practical evaluation (30% final grade) will be by two written tests; or, in case of an average classification in the tests below 9,5, by a recourse exam.
The recourse exam (70% of final grade), can be used by students that had an average classification in the tests below 9,5; or by students that want to improve their final grade (in the latter case, the student must register and pay the due fee). This exam will include only the theoretical (60% final grade) and the theoretical-practical (40% final grade) evaluations. The theoretical-practical evaluation will focus equally on the three themes approached during theoretical-practical sessions.