Molecular Bases of Disease
Code
11179
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
6.0
Teacher in charge
Ligia Raquel Mendonça Faria Marques Saraiva Teixeira, Paula Alexandra Quintela Videira
Weekly hours
4
Total hours
84
Teaching language
Inglês
Objectives
Learning objectives of the curricular unit
- To acquire knowledge and skills about the biochemical mechanisms underlying human disease.
- To be able to relate biochemical mechanisms with associated pathologies
- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.
Subject matter
-Molecular aspects underlying neurological and immune disorders, cardiovascular diseases, infectious diseases, rare diseases, cancer and aging.
- Current molecular methodologies in the context of understanding human pathologies.
Theoretical lectures (1 weekly lecture, 9 – 12 am ):
|
04‐mar |
Introduction and presentation of the course.
Basics of Pathology. Structure, expression and function of genes. Mutations: types and causes and examples of their pathological effects, |
Lígia Saraiva; ITQB Paula Videira; FCM
Paula Videira; FCM |
|
11‐mar |
Monogenic diseases. Dominant versus recessive diseases. |
Paula Videira; FCM
|
|
18‐mar * |
Injury and Cell Death. Apoptosis, necrosis, and cell death pathways. |
Paula Videira; FCM |
|
25‐mar |
Chronic and acute inflammation. |
Paula Videira; FCM |
|
08‐apr |
Autoimmune and inflammatory diseases: mechanisms of disease, and examples of associated disorders and diagnostic methods. |
Paula Videira; FCM |
|
15‐apr |
Kidney function. |
Teresa Catarino, FCT |
|
22‐apr FCM * |
Maintenance mechanisms of genetic information and conditions associated with its amendment. |
Sebastião Rodrigues; FCM
|
|
06‐mai |
Molecular Basis of cancer. |
Sebastião Rodrigues; FCM |
|
13‐mai |
Biomarkers of disease and their detection. |
Paula Videira ; FCM
|
|
20‐mai |
Infectious diseases |
Lígia Saraiva; ITQB |
|
27‐mai |
Factores de virulência |
Lígia Saraiva; ITQB |
|
03‐jun |
Resistência bacteriana |
Lígia Saraiva; ITQB |
|
|
Exam |
|
* In these lectures we will start first by the seminars and then followed by lecture.
Theoretical – pratical / seminar lectures (1 aula semanal de 3 h-tarde 14-17h ):
|
04‐mar |
Cardiovascular and genetic cardiomyopathies; |
Alexandra Fernandes (FCT-UNL) |
|
11‐mar |
Post translational Modifications Glycosylation in cancer and immune response |
Paula Videira; FCM |
|
18‐mar |
Telomeres vs aging and cancer
|
Miguel Godinho ( IGC) |
|
25‐mar |
Cellular and Molecular Aspects of spondyloarthropaties |
Fernando Pimentel (FCM/UNL); FCM |
|
08‐abr |
Alpha synuclein in Parkinson''s disease |
Sandra Tenreiro (IMM/UL); FCM |
|
15‐abr |
Hepatic function. |
Teresa Catarino, FCT* |
|
22‐abr FCM |
Diabetes and insulin resistance; |
Paula Macedo (FCM/UNL) |
|
06‐mai |
Study time |
|
|
13‐mai |
Epigenetic & transcriptional regulation in myeloid disorders |
Antonio Almeida; (IPO) |
|
20‐mai |
Helicobacter pylori, a successful human pathogen; Clinic and diagnosis of infections by Chlamydia trachomatis and Trichomonas vaginalis; |
Mónica Oleastro (INSA) Maria João Simões (INSA) |
|
27‐mai |
Neisseria meningitidis infection - colonization to invasive disease; Fungi |
Maria José Borrego (INSA) Teresa Crespo (ITQB) |
|
03‐jun |
Clinical methods and Mycobacterium tuberculosis |
Isabel Couto (IHMT), |
|
|
|
|
* theoretical lecture
Bibliography
- Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.
- Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.
Books are available at the ITQB library.
Teaching method
The course includes theoretical, practical classes and seminars. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.
The practical classes and seminars will focus on discussion of more specialized subjects. The seminars consist of lectures by invited speakers followed by discussions with active student participation.
Evaluation method
Evaluation
Final examination on the subject of theoretical classroom -60%
Reports of Practice Lessons - 40%
Compulsory attendance of 70%