Active Ingredients
Code
11182
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
3.0
Teacher in charge
Paula Cristina de Sério Branco
Weekly hours
4
Teaching language
Português
Objectives
It is intended that students understand the development process, the design strategy and the organic transformations used in the preparation of drugs.
Subject matter
- Drug Synthesis. Prime considerations in designing a synthesis. The retro-synthetic approach. New trends in synthetic medicinal chemistry.
- The chiral center. The methods for the preparation of enantiomerically pure drugs.
- Classical and bio-assisted organic synthesis
- Combinatorial Chemistry
- Biocatalyzed reactions
- Peptides and peptidomimetic compounds
- Drugs based on a substituted benzene ring
- Opioid analgesics
- Five-membered heterocyclic based-drugs
- Rings that contain three or more heteroatoms
Bibliography
New Trends in Synthetic Medicinal Chemistry, F. Gualtieri, Wiley 2000.
STRATEGIES FOR ORGANIC DRUG SYNTHESIS AND DESIGN, DANIEL LEDNICER, John Wiley & Sons, Inc. (2009)
Evaluation method
2 TEST each worth 50%