Biotechnology of Animal Cells
Code
11465
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
3.0
Teacher in charge
Paula Maria Marques Leal Sanches Alves
Teaching language
Português
Objectives
- Establishment of Animal Cell Technology as a key area in the discovery and development of complex biopharmaceuticals, including recombinant proteins (e.g., monoclonal antibodies), vaccines and viral vectors for gene therapy.
- Relevance of stem cells as products of high therapeutic potential.
- Development of skills in cell culture technologies as in vitro models for basic research and preclinical trials (e.g., primary cultures of brain cells and hepatocytes for toxicology testing).
- Case studies and examples of biotechnological applications of Animal Cell Technology.
- Impact of Animal Cell Technology in Pharma and Small Biotech companies.
- Commercial exploitation of the areas of animal technology and its contextualization in the biotechnology market.
Prerequisites
BSc in Biochemistry, Biology, Biotechnology abnd related areas
Bibliography
“Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications”, R. Ian Freshney, Wiley-Blackwell, 6th edition, 2010
Animal Cell Technology: From Biopharmaceuticals to Gene Therapy, Castilho, Morais, Augusto e Butler (Ed), Taylor and Francis Group (Pub)
Tecnologia do Cultivo de Células Animais de Biofármacos e Terapia Gênica, Morais AM, Castilho L, Augustos EP (Eds), Editora Roca (Pub)
Artigo científicos publicados em revistas internacionais da especialidade com elevado impacto, por exemplo, Nature Biotechnology, Trends in Biotechnology, Biotechnology and Bioengineering, Tissue Engineering, Journal of Biotechnology, Gene Therapy.
Teaching method
This course includes lectures and theoretical/practical. In the lectures, subjects are presented and in the tutorial sessions case studies are presented (analysis of scientific papers). These will allow the consolidation of knowledge that will later be put into practice in the laboratory sessions.
Evaluation method
The evaluation has two components that contribute equally to the final grade: a written examination on the themes explored in lectures (60 %), on the student presentations and discussions during the tutorial sessions and workshops on issues previously suggested by the lecturers (40 %)