Asymmetric Organic Chemistry I
Code
7208
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
6.0
Teacher in charge
Paula Cristina de Sério Branco
Weekly hours
6
Total hours
50
Teaching language
Português
Objectives
In this course students perceive advanced methods in organic synthesis, the mechanisms that govern these transformations, based on the relationship between molecular structure versus reactivity, with a comprehensive understanding of the concepts and applications of asymmetric synthesis
Prerequisites
Students must have the basic knowledge in fundamental organic chemistry and its Reaction Mechanisms allowing them to an understanding and assimilation of the transmitted knowledge.
Subject matter
Theoretical classes
1) stereoselectivity in synthesis: A review of the principles of stereochemistry. Elements of chirality. Prochiral and chiral centers. Stereoisomers. Intermediates and enantiomeric and diastereoisomeric transition state. Reactions on substrates symmetric and asymmetric. Resolution.
2) Reactive intermediates in organic chemistry: carbocations, carbanions, radicals, carbenes, nitrenes and arines. Methods of preparation and reactivity.
3)Reactivity of functional groups: reduction, oxidation and C-C bond formation using transition metal.
Pratical classes
Development of a Salen-Mn catalyst and its application in the oxidation of styrene.
Bibliography
1. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley Sons, Lda, 2007. 2. Dead Ends and Detours, M.A. Sierra, M.C. dela Torre, Wiley, 2003. 3. Modern Methods of Organic Synthesis, W. Carruters and Ian Coldham, 4ª Ed., Cambridge University Press, 2004.
Teaching method
Lectures use modern multimedia techniques. Laboratory classes are carried out in an adequately equipped laboratory. A dynamic interaction student-tutor is established.
Evaluation method
2 MINI-TEST EACH worth 25%
SEMINAR (Group 2 elements) 25% (analysis of an article)
LAB (EVALUATION PRACTICE REPORT +) 25%
It required a minimum score of 9.5 in the theoretical part for approval to the discipline.