Radiation Chemistry
Code
7913
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
6.0
Teacher in charge
Abel José de Sousa Costa Vieira
Weekly hours
3
Total hours
77
Teaching language
Português
Objectives
Formation of students in the new research field of Radiation Chemistry by teaching the basic concepts and applying them to the large areas of applications, with particular attention given to biological and industrial domains.
Prerequisites
First level formation on Physics, Organic Chemistry and Physical Chemistry.
Subject matter
Introduction
Definition, historical devellopment. Ionising radiation.
Interaction of radiation with matter
Energy deposition. X gamma rays. Electrons.
Liner energy transfer (LET). Energy transfer in solution. Radiolytic heterogenities.
Dosimetry
Radiolytic yield. Absorbed dose. Units. Physical and chemical dosimetry.
Radiolysis of water and aqueous solutions
Decomposition of water by ionising radiation.
Radiolytic yield of radical and molecular species.
Reducing and oxidising species. Reactions with solutes. Effect of the reaction medium.
Chemical Reactions induced by Radiation
Experimental techniques. Pulse Radiolysis. Kinetic studies.
Steady-state radiolysis. Product analysis.
Kinetics of ultra.dast reactions
ESR spectroscopy.
Radiation Chemistry of biologic targets
Chemistry and Biology under radiation.
Direct and indirect effect. Oxidative Stress.
Examples of chemical changes related to bological damages.
Radiomimetic systems
Ultrassounds. Radical generation by chemical reaction and photolysis.
Preparative and Industrial applications
Polimerisation, environmental treatment, food conservation, drug sterilisation, radioactive stockage, radiotherapy, radioprotection.
Bibliography
HENGLEIN, A.
Einführung in die Strahlenchemie
Verlag Chemie (1969)
Von SONNTAG, C.
The Chemical Basis of Radiation Biology
Taylor & Francis (1987)
SPINKS, J.W. T. and WOODS, R. J.
An Introduction to Radiation Chemistry
John Wiley & Sons, Inc. , 3th Ed. (1990)
MOZDUMER, A.
Fundamentals of Radiation Chemistry
Academic Press, London (1999)
Von SONNTAG, C.
Free-Radical-Induced DNA Damage an its Repair
Springer, Heidelberg (2006)
SPOTHEIM-MAURIZOT, M.; MOSTAFAVI, M.; DOUKI, T.;
BELLONI, J. eds.
Radiation Chemistry
EDP Sciences, Paris (2008)
WISHART, J.F.; RAO, B.S.M.
Recent Trends in Radiation Chemistry
World Scientific Pub. Co., New York (2010)
Teaching method
Radiation Chemistry is a seminar discipline.
The lectures are of theoretical-pratical type, where theoretical concepts are ilustrated with examples and exrecises.
There is also an experimental component, consisting in radiolysis works for kinetic or product analysis studies.
A final compliment is an ESR seminar and an experimental work in this field.
Evaluation method
The evaluation is based on the monographic theme presented and discussed in seminar, as well as on the reports and discution of the experimental works (radiolysis and ESR.
The final grade is calculated according to the following expression:
Final grade = (TE1 d + TE2 d)*0.25 + Mon A/d*0.5
(TE1, report of ESR work; TE2, report of radiolysis work; Mon, monography)