Advanced Food Toxicology
Code
9756
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Ciências e Tecnologia da Biomassa
Credits
6.0
Teacher in charge
Benilde Simões Mendes, Maria Paula Amaro de Castilho Duarte
Weekly hours
2
Total hours
42
Teaching language
Português
Objectives
Acquisition of knowledge, ability and proficiency concerning (1) the risks associated to the exposure to food toxins; (2) the mechanisms of food toxicology; (3) endogenous and exogenous factors which could be responsible for different individual susceptibilities to food toxins, particularly in what concerns to modulation of chemical toxicity by the several dietary components; (4) the new methodologies which are been developed for toxicity evaluation and for risk analysis.
Prerequisites
Not aplicable
Subject matter
1. Toxicity of the traditional and new foodstuffs and of the food contaminants. Non-organ-directed toxicity (chemical carcinogenesis) and target organ toxicity (liver, kidney and nervous system)
2. Endogenous factors of individual susceptibility to food toxins. Influence on absorption, distribution, biotransformation, excretion and interaction.
3. Exogenous factors of individual susceptibility to food toxins. Influence on absorption, distribution, biotransformation, excretion and interaction.
4. New methodologies to evaluate toxicity: new in vitro and in silicio methodologies. Introduction to the toxigenomic techniques in the toxicology and risk analysis. Approaches for the development of biomarkers of exposure and effect.
Bibliography
Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology, Board on Environmental Studies and Toxicology, Board on Life Sciences, Division on Earth and Life Studies (2007) Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment. NAP (Ed.), EUA.
Klaassen C. D. (2007) Casarett & Doull’s Toxicology: the basic science of poisons, McGraw-Hill Professionla (Publ.), 7th Ed.,EUA., (ISBN 978-0071470513)
Timbrell J.A. (2008) Principles of biochemical toxicology, 4th Edition, Informa Healthcare (Publs.), (ISBN 978-0849373022)
Michael D. Coleman (2010) Human drug metabolism an introduction, 2nd edition, Wiley-Blackweell (Publs.), (ISBN 978 047074217 4)
Teaching method
Theoretical and practical (critical analysis of case studies) sessions.
Evaluation method
Elaboration, presentation and discussion of a specific work subject. Succeed with a minimum grade of 9.5 values (grade of 20 values)