Seminário de Aprofundamento: Long-term inflammation and immune response in the pathogenesis of chronic diseases
Código
101115
Unidade Orgânica
NOVA Medical School | Faculdade de Ciências Médicas
Créditos
5
Professor responsável
Prof. Doutor José Delgado Alves
Língua de ensino
Português /Inglês.
Objectivos
This seminar aims at identifying and characterising the main mechanisms associated with chronic inflammation and how they modulate the immune response to induce disease. Furthermore, it intends to analyse the interface between the inflammatory and immune systems in the context of disease.
The ultimate goal of this seminar is to provide the participants with multiple examples of how chronic inflammation can be an important determinant of different manifestations of disease, from orthopaedics to infection diseases, from neurology to oncology and how it can be a major player not only in the pathogenesis of those conditions, but also as a target for potential new treatments. Furthermore, this approach may suggest new areas for research, both clinical and translational, whilst allowing the students to recognise common points of interest that may provide grounds for future collaboration.
Pré-requisitos
Conteúdo
Inflammation is a fundamental pathologic process responsible for several defence mechanisms including response to injury, tissue repair and immune activation. Chronic inflammation is associated with a vast number of changes at a cellular, biochemical and even organ level, usually linked by an overall endothelium and plasmatic dysfunction. These conditions may result from physical and chemical changes at a molecular level (e.g. oxidation, nitration, etc), disruption of cellular metabolism and control of the immune response, amongst others.
The overall comprehension of the different mechanisms involved will be highlighted in several key areas of chronic disease which are perpetuated by inflammation and dysfunctional immunity such as vascular diseases (e.g. atherosclerosis and thrombosis), neurodegenerative conditions (e.g. Alzheimer´s and Multiple Sclerosis), autoimmune systemic diseases (e.g. Systemic lupus, Antiphospholipid syndrome and vasculitis) and even in particular aspects of many drugs currently used in a wide variety of therapeutic strategies.
Bibliografia
Sem bibliografia pré-definida. Serão fornecidos pelos diferentes palestrantes alguns documentos referentes aos diferentes temas a apresentar na quinzena anterior ao curso.
Método de ensino
Sessões teóricas e discussão de temas e grupo.
Método de avaliação
Avaliação contínua (50%) / Apresentação de projeto (50%).