Tuberculosis and Atypical Mycobacteria
Code
5573007
Academic unit
Instituto de Higiene e Medicina Tropical
Credits
6
Teacher in charge
Miguel Viveiros Bettencourt
Teaching language
Português
Objectives
- Know the global epidemiology of tuberculosis (TB) and other micobacteriosis, demographic factors, mechanisms of transmission and dissemination. How the health system and the laboratory is organized to prevent transmi ssion, in particular of resistant strains and their interconnection with the co-infection with HIV. - Know the biological characteristics of etiological agents of TB and other micobacteriosis; - Know and describe the imunofisiopathology of mycobacteriosis and the clinical manifestations of the various forms of TB; - Know the classic techniques of clinical micobacteriology, theoretical and practical knowledge of laboratory techniques for TB, leprosy and other micobacteriosis diagnosis. - Know the basics of management of laboratories in programmes to combat TB and procedures for monitoring therapy. The external and internal quality control.
Prerequisites
Conclusao do 1.º ciclo em qualquer curso da área das Ciências da Vida ou da Saúde.é obrigatória a frequência de 2/3 das aulas. Os alunos com pelo menos 2/3 de frequência, serão admitidos a exame final.
Subject matter
- Clinical, epidemiological and therapeutic aspects of tuberculosis. Tuberculosis and other mycobacterioses. - Genus Mycobacterium. Cell wall and pathogenesis, diagnosis, resistance and rational development of drugs. - Emerging human mycobacteriosis. - Tuberculosis and extensively resistant "superbug". Security measures - Standard procedures for mycobacterial laboratory diagnosis. Collection and transport of products, staining, decontamination and concentration, culture techniques. Antibiotic susceptibility tests. Quality control in the laboratory. - TB Immunology: protective immunity against tuberculosis. Immunological mechanisms triggered by vaccination with BCG. Immune response to infection by M. avium in immunosuppression. - Practice (s) and theoretical-practice sessions: processing of samples for isolation of Mycobacteria and culture techniques. Methods of identification. Drug susceptibility tests.
Bibliography
Portugal, I. and Viveiros M. (2014) Mycobacterium In: Microbiologia Médica, António Meliço-Silvestre , Helena Barroso e Nuno Taveira editores, Lidel, Edições Técnicas, Lisboa, Portugal. McHugh, T. D. (2012) Tuberculosis: Advances in Molecular and Cellular Microbiology, C A B Intl Press, London,. Schlossberg D. (2011) Tuberculosis and Nontuberculous Mycobacterial Infections, ASM Press, Washington. Viveiros M. and Atouguia J. (2008) Tuberculose – Saúde Tropical. Edição Universidade Aberta. Palomino J. C., et al (2007) Tuberculosis 2007 - From basic science to patient care, First Edition, 687 pp.
Teaching method
- Total number of working hours- Total 16 contact hours: 48 hours of work T: Theorectical lectures hours 2/week (of 8 hours, for 4 weeks) TP- Theoretical-practical classes. 2/week time (of 8 hours, for 4 weeks) 1) Theoretical, slide show based, accompanied by indication of supplementary bibliography. 2) Lectures with presentation and resolution of practical cases of application of some of the methodologies discussed the cases of diagnostic / monitoring / characterization of mycobacterial infections and characterization of the profile of drug resistance.
Evaluation method
A avaliação será feita através da realização de um exame final de avaliação de conhecimentos, com perguntas de escolha múltipla, incidindo sobre os conteúdos das aulas teóricas, teórico-práticas e laboratoriais.A escala de classificação do exame será de 0 a 20 valores. Os alunos com classificação igual ou superior a 10 valores serão aprovados.