Developmental Biology

Code

11162

Academic unit

NOVA Medical School|Faculdade de Ciências Médicas

Department

MCM

Credits

3

Teacher in charge

Prof. Doutor José Belo

Objectives

The objective of this Curricular Unit is to provide a solid and in depth knowlege of the genetic, molecular and morphogenetic basis of the initial stages of animal Developmental Biology. This course will also contribute to the acquisition of the following skills: • Use of basic knowledge to solve problems of human disease and / or treatment. • Critical appraisal of scientific articles. • Ability to present and discuss a scientific subject.

Prerequisites

 

Subject matter

Introduction Basic concepts in Developmental Biology. Spermatogenesis and oogenesis. Fertilization Introduction to Drosophila, Chicken, Xenopus, Zebrafish, and mouse as model systems. Gene expression and Cell differentiation Gene expression and body patterning. Establishment of body axis in vertebrates. Mechanism of induction of head formation. Establishment of Left-right asymmetry. Morphogenesis. Regulation of cell polarization and cell adhesion Polarized and transepithelial cell migration. Tissue morphogenesis and organogenesis. Wound healing and tissue regeneration. Regulation of cell proliferation and stem cell niche

Bibliography

- Developmental Biology, 10th Edition (2013). Scott F. Gilbert, Sinauer Associates   - Larsen’s Human Embryology, Gary Schoenwolf, Steven Bleyl, Philip Brauer and Philippa Francis-West. Churchill Livingstone, 4th Edition, 2009.   - Essential Developmental Biology, 2nd Rev. Edition, 2006. Jonathan M. W. Slack. Blackwell Publishing,

Teaching method

Part of the teaching time will be devoted to the presentation and discussion of various scientific articles, provided by the teachers. The presentations of papers will be performed by the students.

Evaluation method

The evaluation will be done through a presentatio

Courses

• Integrated Master Degree in Medicine