Molecular Mechanisms of Disease
Code
11207
Academic unit
NOVA Medical School|Faculdade de Ciências Médicas
Credits
3
Teacher in charge
Prof. Doutor Miguel Seabra
Teaching language
Portuguese
Objectives
This UC is on the 5th year of MIM and addresses molecular mechanisms of clinical subjects. The subjects are: Aging and Oxidative stress; Chronic inflammation and tecidual response; Atherosclerosis; Amyloid and degenerative diseases, Oncobiology; Rare Diseases, New therapies. These are descriptive lectures and have the aim that students can understand the molecular mechanisms of each theme and are able to discuss it. Than we have practical classes where the students will work in group on a mechanism and have to address a new scientific question, than they will present orally their work. We pretend that students be able to apply the acquired knowledge, acquire the critical spirit and scientific discussion as well as the capacity of find scientific literature when have a new problem. This UC will allow to students do develop several competencies, like: presenting scientific subjects in English language, learning the molecular mechanisms related with pathologies and do the clinical translation.
Prerequisites
Subject matter
Aging: Molecular Theories. Oxidative stress and free radicals;
Cell death: Missfuction and disease association.
Chronic inflammation and tecidual resposes
Biological and biochemical processes are the bases of inflammatory response;
Concept of resistance and/or tolerance to dame tissue;
Intracellular signalling activation to prevent dame tissue by inflammatory response;
diseases.
Neurodegenerative disesases and amiloide
Examples of phatogenesis by amyloid.
Oncobiology
Oncogenes and tumor supressor / cell cycle;
Intracellular signalling deregulation;
Tumor microenvironment in molecular processes of metastasis and angiogenesis
Rare Diseases
Definition, examples, transmission and social problems.
Therapeutic approaches: enzymatic, genetic and cellular
New Therapies
Genic therapies;
Cell therapies
Personalized medicine
Bibliography
All the teachers will give additionaly bibliography in the form of scientific papers, that are available onlin in Moodle.
Teaching method
Practical classes have 2hr duration weekly and begin after theoretical classes are finished. These are tutorial classes. The students have to define a new scientific question between the seven subjects lectured.
Evaluation method
Practical continuous evaluation component (50% or 70% of the CU final grade)
The student evaluation in the practical component will include their performance, assiduity (student have to be present at least to 2/3 of the classes), the abstract (250 words) and presentation. For the student works chosen to be presented on the workshop the practical component have a weighing of 70% on the final grade, to the others the weighing will be 50%.
The evaluation is quantitative from 0 to 20 values. With a rating superior to 9,5 values, the student have access to the Final Exam, with less than that will reproof.