Synthetic and Systems Biology
Code
10827
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
6.0
Teacher in charge
Isabel Maria Godinho de Sá Nogueira, Rui Manuel Freitas Oliveira
Weekly hours
4
Total hours
85
Teaching language
Português
Subject matter
Module I - Systems Biology
1 Introduction to Systems and Synthetic Biology
2 Constraints based modeling
2.1 Metabolic flux analysis
2.2.Flux balance analysis
2.3. Gene regulation networks
3 Statistical modeling
3.1 Nonparametric modeling
3.2. Classification methods
3.3 Linear and non-linear regression methods
4. Design of standard biological parts
5. Design of synthetic biological circuits
Module II - Synthetic Biology
1- Introduction to Synthetic Biology
2- Synthetic molecules
- Proteins
- Nucleic Acids
3- Genetic parts to program bacteria
4- Gene regulatory circuits
- collective behavior engineering
5- Synthetic Biology and Yeast Metabolic Engineering
6- RNA in Synthetic Biology
7- Challenges in Synthetic Biology
Bibliography
Mainly scientific papers.
Books:
- D. Wilkinson. Stochastic Modeling for Systems Biology, Chapman&Hall, 2006
- Alon, Uri. An Introduction to Systems Biology: Design Principles of Biological Circuits. Boca Raton, FL: Chapman & Hall, 2007. ISBN: 9781584886426.
- Fu P. and Panke S. Systems Biology and Synthetic Biology, John Wiley & Sons, Inc. 2009