Molecular Bases of Disease
Code
11179
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Ciências da Vida
Credits
6.0
Teacher in charge
Ligia Raquel Mendonça Faria Marques Saraiva Teixeira, Paula Alexandra Quintela Videira
Weekly hours
4
Total hours
68
Teaching language
Português
Objectives
To acquire knowledge and skills about the biochemical mechanisms underlying human disease.
-To understand metabolic processes and associated pathologies.
- To be able to relate biochemical mechanisms with associated pathologies
- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.
- To be able to search and critically interpret the literature.
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.
Subject matter
- Molecular aspects underlying several diseases. It includes injury and cellular homeostasis, genetic deficits, changes in metabolism, inflammation and infection, cancer and aging. Seminars on various diseases: metabolic, immune, cardiovascular, infectious, rare diseases, cancer and aging.
- Current therapies and methodologies in the context of understanding of human diseases.
Theoretical lectures (1 weekly lecture, 9 – 12 am ):
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Introduction and presentation of the course. Basics of Pathology.
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Injury and Cell Death. Apoptosis, necrosis, and cell death pathways. |
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Monogenic diseases. Dominant versus recessive diseases. Mutations: types and causes and examples of their pathological effects. |
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Chronic and acute inflammation. |
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Autoimmune and inflammatory diseases: mechanisms of disease, and examples of associated disorders and diagnostic methods. |
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Kidney function. |
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Maintenance mechanisms of genetic information and conditions associated with its amendment. |
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Molecular Basis of cancer. |
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Biomarkers of disease and their detection. |
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Infectious diseases. |
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Virulence factors. |
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Bacterial resistance |
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Questions and answers
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Theoretical – pratical / seminar lectures (1 aula semanal de 3 h-tarde 14-17h ):
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Cardiovascular and genetic cardiomyopathies |
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Glycosylation and diseases |
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Telomeres vs aging and cancer |
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Cellular and Molecular Aspects of spondyloarthropaties |
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Alpha synuclein in Parkinson''''s disease |
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Hemodynamic Disorders, Thromboembolic Disease, and Shock |
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Diabetes and insulin resistance. |
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Kidney liver injury |
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Epigenetic & transcriptional regulation in myeloid disorders. |
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Helicobacter pylori, a successful human pathogen; |
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Neisseria meningitidis infection - colonization to invasive disease. |
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Clinical methods and Mycobacterium tuberculosis. |
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Bibliography
- Robbins Basic Pathology, 9th Edition, by Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS and Jon Aster, MD. ISBN: 978-1-4377-1781-5
-Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.
-Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.
Books are available at the ITQB FCT libraries.
Teaching method
The course includes theoretical, theoretical-practical classes and seminars. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.
The theoretical-practical classes and seminars will focus on discussion of specialized subjects. The seminars include lectures by invited speakers followed by discussions with active student participation. Also includes student’s seminars.
Evaluation:
Final examination on the subject of theoretical classroom -40%
Seminars _ discussion_Reports - 60%
Compulsory attendance of 75%
Evaluation method
Final examination on the subject of theoretical classroom -40%
Discussions of cases and seminars - 60%
Compulsory attendance of 75%