Regenerative Medicine Strategies
Code
1091012
Academic unit
Faculdade de Ciências Médicas
Credits
5
Teacher in charge
Gabriela Silva
Teaching language
English
Objectives
Understand the biological mechanisms of repair versus regeneration.
Understand the potential of regeneration strategies based on cell therapies.
Understand the role of biomaterials in regenerative medicine.
Contact with regeneration strategies and tissue repair.
Discuss strategies for regenerative medicine.
Develop discussion skills of specific topics in regenerative medicine.
Prerequisites
Subject matter
Fundamentals of Regenerative Medicine. Historical perspective.
Regeneration mechanisms. Homeostasis and tissue repair in adult mammals.
Principles and mechanisms of stem cell biology. Inducing cellular reprogramming for generating stem cells.
Sources of stem cells. Ethical issues.
Cell Therapy and Gene Therapy - applications in regenerative medicine.
Biomaterials and Regenerative Medicine.
Tissue regeneration strategies: reconstruction of organs using scaffolds and the extracellular matrix of decellularized organs.
Biomaterials as scaffolds for promotion of tissue regeneration.
Drug delivery systems.
Tissue regeneration strategies based on three-dimensional carriers (scaffolds).
Stem cells and tissue regeneration.
Regeneration strategies: examples.
Nano-strategies for tissue regeneration.
Discussion of papers about tissue regeneration strategies.
Bibliography
Principles of Regenerative Medicine, 2nd Edition (2010).
Anthony Atala, Robert Lanza, James A. Thomson, and Robert Nerem.
Academic Press
Regenerative Biology and Medicine, 2nd Edition (2012).
David L. Stocum.
Academic Press
Teaching method
The first classes will be theoretical and will serve to present the basic concepts of the scientific area underlying the field that is subject of this curricular unit. Classes in a laboratory environment (practical classes) aim to introduce students to the practice associated with tissue regeneration strategies, and in a seminar format, in which the latest developments in areas related to regenerative medicine will be presented.
This course also contemplates case study and scientific articles discussions.
Evaluation method
The evaluation criteria are: scientific content of presented work, graphical presentation, discussion of own presentation, and discussion of other papers.
Presence is mandatory in 75% of classes.