Molecular Bases of Disease
Code
11179
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Ciências da Vida
Credits
6.0
Teacher in charge
Ligia Raquel Mendonça Faria Marques Saraiva Teixeira, Paula Alexandra Quintela Videira
Weekly hours
4
Total hours
84
Teaching language
Inglês
Objectives
To acquire knowledge and skills about the biochemical mechanisms underlying human disease.
-To understand metabolic processes and associated pathologies.
- To be able to relate biochemical mechanisms with associated pathologies
- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.
- To be able to search and critically interpret the literature.
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.
Subject matter
Theoretical lectures (1 weekly lecture, 9 .30 – 12 am ):
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5-3 |
Introduction and presentation of the course.
Basics of Pathology. |
Paula Videira
Paula Videira |
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12-3 |
Injury and Cell Death. Apoptosis, necrosis, and cell death pathways. |
Margarida Braga |
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19-3 |
Infectious diseases. |
Lígia Saraiva |
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26-3
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Virulence factors. |
Lígia Saraiva |
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9-4 |
Bacterial resistance |
Lígia Saraiva |
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16-4 |
Monogenic diseases. Dominant versus recessive diseases. Mutations: types and causes and examples of their pathological effects. |
Paula Videira |
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23-4 |
Inflammation and Repair Chronic and acute inflammation. |
Paula Videira |
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30-4
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Autoimmune and inflammatory diseases: mechanisms of disease, and examples of associated disorders and diagnostic methods. Hemodynamic disorders |
Paula Videira |
|
7-5 |
Liver function. |
Paula Videira Teresa Catarino |
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14-5 |
Maintenance mechanisms of genetic information. Molecular Basis of cancer. |
Sebastião Rodrigues; FCM |
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21-5 |
Biomarkers of disease and their detection. |
Paula Videira
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28-5 |
Clinical case |
Paula Videira
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4-6 |
Teste |
Paula Videira Lígia Saraiva |
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Theoretical – pratical / seminar lectures (1 aula semanal de 3 h-tarde 13-15h ):
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12-3
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19-3 |
Epidemiology and Pathogenesis of Clostridium difficile infection (CDI) |
Mónica Oleastro |
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26-3
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Sexually transmitted bacterial infection |
Maria José Borrego |
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9-4 |
Clinical methods and Mycobacterium tuberculosis |
Isabel Leitão Couto |
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16-4 |
Carbon monoxide targeting mitochondria: modulation of apoptosis and cell metabolism |
H Vieira |
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23-4 |
Cardiovascular and genetic cardiomyopathies; |
A Fernandes |
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30-4
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Cellular and Molecular Aspects of spondyloarthropaties |
F Pimentel |
|
7-5 |
Alpha synuclein in Parkinson''s disease |
S Tenreiro |
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14-5 |
Diabetes |
P Macedo |
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21-5 |
Glycosylation and diseases |
P Videira |
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28-5 |
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Bibliography
- Robbins Basic Pathology, 9th Edition, by Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS and Jon Aster, MD. ISBN: 978-1-4377-1781-5
-Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.
-Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.
Books are available at the ITQB FCT libraries.
Teaching method
The course includes theoretical, theoretical-practical classes and seminars. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.
The theoretical-practical classes and seminars will focus on discussion of specialized subjects. The seminars include lectures by invited speakers followed by discussions with active student participation. Also includes student’s seminars.
Evaluation method
Final test on theoretical class themes - (minimum 10 values) - 70%
Case resolution -5%
Seminars ( writting of seminars summary)- 25%
Classification attributed to the seminars: I (0), S (10), B(15), B+ (18), MB (20)
The final grade results from the weighting of the grade of all seminars.
More than 3 absences to seminars - the practical part is considered to be not done.
The final mark (seminars+ case) is kept for 2 years.
Absences at seminars imply a zero mark.
Delays of more than 20 minutes after the start of the seminar class will be counted as an absence.