Molecular Alterations in Cancer
Code
11130
Academic unit
Nova Medical School | Faculdade de Ciências Médicas
Department
TRA - Genetics, Human Toxicology and Oncology
Credits
3
Teacher in charge
Prof.ª Doutora Jacinta Serpa
Teaching language
Portuguese
Objectives
Understanding molecular mechanisms underlying carcinogenesis and cancer progression.
Initiation of the students in the practice of basic research in biomedicine.
Acquisition of theoretical knowledge and practical techniques of molecular and cytological and histological analysis.
Evaluation of data and compilation of experiences with scientific rigor.
Acquisition of skills in scientific communication.
Prerequisites
Subject matter
Genetic alterations (mutations and structural DNA) and epigenetic (changes in chromatin that regulate gene expression) involved in the development and progression of cancer, giving primary emphasis to the pathophysiology and morphology of lesions.
Signaling pathways which are predominantly altered in cancer, including WNT pathway, MAPK and PI3K.
Cell adhesion molecules
Extracellular matrix component
Metabolic pathways which are predominantly altered in cancer, namely aerobic and anaerobic glycolysis and oxidative respiration, gluconeogenesis, synthesis and ß-oxidation of fatty acids and cholesterol.
Experimental work in vitro using cell lines and molecular biology techniques
Preparation of scientific communications, oral and paper.
Bibliography
The bibliography will be available along the UC and students will be directed to carry out literature.
Teaching method
LECTURES-Theoretical approach to the subjects listed in the "curriculum" of CU;
PRACTICAL LECTURES- presentation of works developed by students in the UC, and
PRACTICAL CLASSES- development of experimental work, whenever possible, students will contact with professionals who are active on issues that are addressed in UC.
Evaluation method
Methods of assessment:
Development of a scientific report in an article format;
Presentation and Discussion;
Written examination.
Students with a special study (without compulsory attendance) will be evaluated in a written examination).
For the purpose of improving UCO's grade (requested by the student), the evaluation will be carried out in the same way as the evaluation of students with special status.
The proof review process follows the guidelines of the current MIM Pedagogical Regulation.
Courses
