Innovative Immunotherapies
Code
11192
Academic unit
Nova Medical School | Faculdade de Ciências Médicas
Department
TRA - Medicina Celular e Molecular
Credits
3
Teacher in charge
Prof.ª Doutora Paula Videira
Teaching language
Portuguese
Objectives
At the end of the course, the student should have the ability to:
1. Understand the Immunotherapy and its clinical applications.
2. Evaluate the role of various immunotherapeutic strategies in the treatment of diseases.
3. Report based on acquired knowledge, important issues related to the design of therapeutic measures.
4. Interpret scientific articles and pre-clinical and clinical trials in this area
5. Communicate / explain published results.
6. Develop a critical evaluation of therapeutic approaches and new discoveries, compared to more traditional approaches.
Relate the concepts of Immunotherapies in the discussions and integration of information.
Prerequisites
Subject matter
General topics:
- Introduction to immunotherapy
- Immune Tolerance: Autoimmunity, Transplantation and hypersensitivity
- Vaccination and new vaccines
- Tumor Immunology
- Cellular circuits in chronic inflammation: identification of biomarkers and therapeutic targets
- Antibody Engineering
- Antigen immunotherapy targets
Specific themes:
- Clinical applications of therapeutic antibodies
- T-cell based therapies
- Dendritic cell based therapies
- Immunotherapy with mesenchymal cells and other cell therapies in clinical practice
- Cytokines as therapeutic targets
- Genetic engineering in immunotherapy
- Ethical / legal and commercial considerations in new immunotherapies
Bibliography
Cancer Immunotherapy- Paradigms, Practice and Promise, Curiel, Tyler J. (Ed.) 2013, IX,
Cellular and Molecular Immunology, Saunders/Elsevier, 2011 by Abbas, Lichtman, and Pillai
Janeway's Immunobiology 9th Ed. Kenneth Murphy, Casey Weaver ISBN:9780815344452
Kuby Immunology; Kindt, Goldsby, Osborne
Fundamentos de Imunologia, Lidel, Fernando A. Arosa, Elsa M. Cardoso, Francisco C. Pacheco
Teaching method
The course is organized in, theoretical and practice lectures. Theoretical lectures include general and specific topics, seminars, followed by theoretical-practical classes, where students will be divided by groups to work in preparing a presentation and / or discussion of related articles and / or review writing.
Evaluation method
The student will be evaluated according to the weighted average of: 1) a written examination (50% weighting) that includes material on themes explored in all classes, subject of student presentations and discussions in forums; 2) presentation of seminars and / or discussion of articles on the topics of the course unit (40% weighting); 3) web forum (weighting 10%). In the case of an improvement exam or special period, the student can choose a 100% global exam or an exam that includes the subject of the test with a value of 50% and in this case the student maintains the grade achieved for the component "presentation seminar /article and forum.
The evaluation criteria are the notes on the examination, and presentations. Attendance at lectures is optional but the presence in the practical and theoretical-practical is mandatory.
Practical evaluations of previous school years are not valid.
The timing of the evaluations (date, time and place) will be published online in the option page (Moodle), and the procedures for test query.