Universidade Nova de Lisboa

Universidade Nova de Lisboa

NOVA Medical School | Faculdade de Ciências Médicas

General Pharmacology

Code

11119

Academic unit

Nova Medical School | Faculdade de Ciências Médicas

Department

TRA - Functional Sciences and Therapeutic Targets

Credits

4

Teacher in charge

Prof.ª Doutora Maria Emília Monteiro

Teaching language

Portuguese

Objectives

The learning outcomes are mainly cognitive: memory, comprehension, application of concepts and problem solving.

In small groups classes, attitudes and soft skills are also addressed.

Learning outcomes:

• Identify molecular targets and pathways that can be manipulated by drugs

. Identify drugs that are available

. Justify the main pharmacodinamic and pharmacokinetics principles

. Apply the pharmacodinamic and pharmacokinetics principles to specific drugs/situations

. Integrate the principles of pharmacology in the process of drug evaluation (efficacy, safety and quality)

. Apply the principles of drug evaluation to specific situations: generics and biosimilars

 

Prerequisites

 

Subject matter

  1. Introduction to Pharmacology. Concepts
  2. From drug origin to therapeutic use: the life cycle of drugs
  3. General principles of pharmacokinetics
  4. General principles of pharmacodynamics
  5. Drugs that are proteins.
  6. Generics and biossimilars
  7. Pharmacology of cellular proliferation: general mechanisms
  8. Pharmacology of the ionic transport
  9. Local anaesthetics
  10. General anaesthetics
  11. Drugs that modify the cholinergic transmission
  12. Drugs that modify the adrenergic transmission
  13. General pharmacology of inflammation
  14. General pharmacology of histamine
  15. Drug toxicity
  16. Pharmacological basis of precision medicine

Bibliography

BASIC & CLINICAL PHARMACOLOGY, B. G. Katzung and A.Trevor, 14th edition, McGrawHill Companies, Inc., 2017

 

RANG & DALE'S PHARMACOLOGY, Rang et al., 8th edition, Elsevier/Churchill Livingstone, 2015

 

PRINCIPLES OF PHARMACOLOGY – The Pathophysiologic Basis of Drug Therapy

D. E. Golan, E.J. Amstrong, A. W. Armstrong, 4th edition,  Wolters Kluwer, 2017

 

TERAPÊUTICA MEDICAMENTOSA E SUAS BASES FARMACOLÓGICAS

S.Guimarães, D.Moura e P.Soares da Silva, 6ª edição, Porto Editora, 2014

 

GOODMAN & GILMAN’S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS.

L. L. Brunton, B. C. Knollmann,  R.  Hilal-Dandan, 13th Edition, McGrawHill,

2017

 

Artigos científicos

www.ncbi.nlm.nih.gov

http://pcs.isiknowledge.com

 

Classificação de receptores

http://iuphardb.org

 

Autoridade Nacional do Medicamento e Produtos de Saúde, I.P

www.infarmed.pt

 

Resumo das características dos fármacos aprovados pela agência europeia do medicamento

http://www.emea.europa.eu/htms/human/epar/eparintro.htm

 

Teaching method

General Pharmacology is a one semester course that has a workload of 4 ECTS with 3 contact hours /week : 2h of lectures and 1h  of  formative evaluation classes in small groups (n<16).

Teaching language is Portuguese but the slides content and bibliography are in English

Evaluation method

Final evaluation includes the distributed evaluation obtained in small groups teaching (30%); a written multiple choice test (70%) in Portuguese (compulsory) and an oral (optional) exam. A minimal grade of 10/20 in both exams is needed to get approval, except for foreign students where no minimal scores in the written test are required

Courses