Bioinformatics in Biomedicine
Code
10776
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Ciências da Vida
Credits
6.0
Teacher in charge
Ana Rita Fialho Grosso, João Manuel Gonçalves Couceiro Feio de Almeida
Weekly hours
4
Total hours
91
Teaching language
Português
Objectives
1. Understand the fundamental concepts behind experimental design, data handling and interpretation of results.
2. Obtain practical knowledge in the application of R-based bioinformatics tools.
3. Understand the importance of bioinformatics in the biomedical field.
Prerequisites
Basic knowledge of Molecular Genetics and Statistics.
Subject matter
Topics
1. Experimental design
2. Descriptive statistics and exploratory analyses
3. Statistical inference 1: comparing means and medians
4. Statistical inference 3: analysis of variance
5. Statistical inference 3: data analysis
6. Analysis of large-scale data
7. Association between two of more variables
8. Multivariate analysis
9. Identification of transcriptome alterations
10. Functional Annotation and Analysis
11. Survival Analysis
Bibliography
Teaching method
A limited number of lectures is scheduled. Autonomous study is encouraged. Exercises with hands-on will be carried out in practical sessions using personal computers.
Evaluation method
The evaluation consists in one individual test and a two group projects, contributing respectively for 40% (test) and 30%+30% (group projects) of the final grade. The execution of each evaluation element is mandatory, with a minimum grade of 9 on each.
The test is individual, without consulting and performed during 1 hour.
The group project consists in the data analysis, interpretation and integration of results in order to answer a biological question, with further preparation of a scientific manuscript.