Active Ingredients
Code
11182
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
3.0
Teacher in charge
Paula Cristina de Sério Branco
Weekly hours
2
Total hours
28
Teaching language
Português
Objectives
It is intended that students understand the development process, the design strategy and the organic transformations used in the preparation of drugs.
Subject matter
- Drug Synthesis. Prime considerations in designing a synthesis. The retro-synthetic approach. New trends in synthetic medicinal chemistry.
- The chiral center. The methods for the preparation of enantiomerically pure drugs.
- Classical and bio-assisted organic synthesis
- Combinatorial Chemistry
- Biocatalyzed reactions
- Peptides and peptidomimetic compounds
- Drugs based on a substituted benzene ring
- Opioid analgesics
- Five-membered heterocyclic based-drugs
- Rings that contain three or more heteroatoms
Bibliography
New Trends in Synthetic Medicinal Chemistry, F. Gualtieri, Wiley 2000.
STRATEGIES FOR ORGANIC DRUG SYNTHESIS AND DESIGN, DANIEL LEDNICER, John Wiley & Sons, Inc. (2009)
Evaluation method
2 TEST each worth 50%